Among various topics worth intellectual consideration, LGBT+ science and research in 2018 gave us a better understanding of gender identity, sexual desire and same-sex reproduction. In the field of medicine, there have been continuing signs of effective HIV treatmentvia daily antiretroviral therapy (ART), while an experimental vaccine for the virus, so far only trialled on small animals, is due to begin testing on humans next year. This year also marked the first international celebration of LGBTSTEM Day, an initiative organised by a group of associations working to support LGBT+ rights in the fields of Science, Technology, Engineering and Maths (STEM).